WHAT IT IS

Rejuran is an advanced skin rejuvenation treatment formulated with polynucleotides (PNs), biocompatible molecules derived from salmon DNA. Originally developed in South Korea, Rejuran has become a go-to solution across Asia and now in the U.S. for addressing visible signs of skin aging, environmental damage, and poor texture.

By working at the cellular level to stimulate tissue regeneration, Rejuran offers a natural, regenerative approach to skin renewal, improving elasticity, tone, and hydration from within.

WHAT IT DOES

  • Stimulates Cellular Repair – Helps damaged skin heal from the inside out by boosting fibroblast activity and collagen production.
  • Improves Skin Texture & Tone – Refines rough patches, minimizes pores, and creates a smoother, more even surface.
  • Reduces Inflammation & Redness – Anti-inflammatory properties soothe sensitive or irritated skin, promoting a more balanced appearance.
  • Enhances Hydration & Elasticity – Increases moisture retention and strengthens the skin barrier for plumper, firmer skin.

UNDERSTANDING THE SCIENCE

Polynucleotides: Nature’s Skin Rebuilders

Polynucleotides are chains of nucleotides—fundamental building blocks of DNA and RNA. The polynucleotides in Rejuran are extracted and purified from salmon DNA, chosen for its similarity to human DNA and excellent biocompatibility. Once injected, these molecules:

  • Stimulate skin cells (fibroblasts) to produce collagen and elastin
  • Repair damaged DNA and promote tissue regeneration
  • Increase blood flow and skin metabolism
  • Restore the skin’s protective barrier

The result is healthier, younger-looking skin that’s achieved not by forcing change, but by encouraging your body’s natural renewal mechanisms.

Rejuran Healer vs. Other Forms

  • Rejuran Healer – The classic formulation is designed to revitalize and regenerate aging or damaged skin.
  • Rejuran I – Tailored for delicate areas like under the eyes to smooth fine lines and restore elasticity.
  • Rejuran S – Formulated to treat acne scars by promoting collagen remodeling in deeper layers.
  • Rejuran HB (Hydro Booster) – Combines PNs with hyaluronic acid for added hydration and glow.

BENEFITS

  • Visible smoothing of wrinkles & fine lines
  • Dramatic improvement in skin texture & resilience
  • Balanced tone & reduced redness
  • Improved barrier function for long-term skin health
  • Safe for all skin types, including sensitive skin
  • Minimally invasive with no downtime

Most patients describe their skin as feeling stronger, firmer, and “more alive” after just a few sessions.

YOUR REJURAN EXPERIENCE

Consultation

Every treatment starts with a detailed consultation. We’ll assess your skin’s condition, concerns, and sensitivity levels to determine the best Rejuran formulation and delivery method for your needs.

Pre-Treatment Guidelines

  • Avoid NSAIDs or blood thinners for 48 hours before
  • Do not use retinol or harsh exfoliants for five days
  • Stay out of the sun and avoid tanning beds
  • Arrive with clean, makeup-free skin

Treatment Session

Rejuran is typically administered via microinjections or combined with microneedling. Sessions last 30 to 45 minutes. A topical anesthetic is applied beforehand to ensure comfort. You may experience slight pricks or tingling, but the procedure is generally well-tolerated by most individuals.

Post-Treatment Care

  • Mild redness, swelling, or tiny bumps may appear for one to two days
  • Avoid sun exposure, heat, saunas, and vigorous exercise for 48 hours
  • Use a gentle cleanser and a rich, soothing moisturizer
  • Apply SPF 30+ daily to protect your renewed skin

Treatment Frequency

For optimal results, we recommend a series of three to four sessions spaced three to four weeks apart, followed by maintenance treatments every six to nine months.

MAINTAINING YOUR RESULTS

Rejuran initiates internal healing, but lasting radiance comes from consistency, both in-office and at home.

Prioritize Barrier Repair

Rejuran strengthens your skin’s foundational layers, but you’ll need to protect and nourish your barrier for sustained improvement. Look for skincare products containing:

  • Ceramides – Reinforce the skin’s natural lipid layer
  • Niacinamide (Vitamin B3) – Calms redness, reduces trans-epidermal water loss, and improves elasticity
  • Peptides – Signal your skin to produce collagen and elastin

Avoid harsh surfactants (like sulfates), stripping exfoliants, or alcohol-based toners for at least a week after treatment. These can disrupt the healing process and compromise your results. Choose gentle, fragrance-free cleansers and apply occlusive moisturizers that lock in hydration and support the skin’s newly revitalized structure.

Hydration Is Key

Drink plenty of water daily and use products containing hyaluronic acid and panthenol. Well-hydrated skin supports cellular turnover and elasticity.

Antioxidant-Rich Skincare

While Rejuran boosts your skin’s ability to repair itself, environmental stressors like pollution and UV radiation can still degrade collagen and trigger pigmentation. Protect your skin daily with:

  • Vitamin C serums – Brighten tone and neutralize free radicals
  • Green tea extract – Reduces inflammation and shields against oxidative stress
  • Resveratrol – Strengthens the skin’s defense mechanisms

Apply antioxidant serums in the morning under SPF to enhance skin resilience and extend the visible benefits of your treatments.

Limit Stress & Sleep Well

Lack of sleep and elevated cortisol levels directly impact your skin’s appearance. Aim for seven to nine hours of restful sleep and integrate stress-management practices like mindfulness or moderate exercise.

FAQs

Is Rejuran safe for all skin tones?

Yes. Rejuran does not contain harsh chemicals or light-based energy, making it safe for all Fitzpatrick skin types, including melanin-rich complexions.

When will I see results?

Some patients notice smoother texture and improved hydration within a week. However, Rejuran is designed for long-term rejuvenation, with full results typically visible four to six weeks after your second or third treatment. Skin continues to improve over time as collagen remodeling progresses.

Is Rejuran the same as filler?

No. Rejuran is a biorevitalizer, not a volumizing filler. It doesn’t “fill” areas—it stimulates regeneration, helping the skin heal and thicken over time for natural firmness and glow. You can combine Rejuran with other injectables like HA fillers or neuromodulators, depending on your goals.

Does it hurt?

Discomfort is minimal. A numbing cream is applied before treatment, and most clients report only slight pressure or tingling. Any post-treatment sensitivity resolves within a day or two.

Can Rejuran be used on the neck or hands?

Yes! Rejuran is versatile and can be used on the neck, chest, back of hands, and under the eyes—anywhere skin appears thin, crepey, or damaged.

Schedule Your Personalized Consultation Today

Experience the regenerative power of Rejuran at Luminance Regenerative Beauty & Wellness in San Jose, CA. Whether you’re looking to reverse signs of aging, reduce redness, or restore overall skin vitality, our team will craft a customized plan that meets your goals.

Every face tells a story, and Rejuran helps you rewrite yours with smoother texture, balanced tone, and a naturally radiant finish. Book your consultation today and rediscover what healthy skin feels like.

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